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Senior Scientist - Protein Binder Discovery

Cambridge

CK Group are working in partnership with Nxera Pharma UK Limited (formerly Sosei Heptares) to recruit a lab-based Senior Scientist in Protein Binder Discovery based in Granta Park, Cambridge.

Company:

Nxera Pharma is a technology powered biopharma company, in pursuit of new specialty medicines to improve the lives of patients with unmet needs in Japan and globally, focused on therapeutic areas in inflammation diseases, neurology and immunology.

The Role:

The successful candidate will join the Protein Binders Discovery Team at Nxera Pharma and will also be part of the wider Biochemistry and Biophysics teams. The successful candidate will use phage display expertise to select protein binders against therapeutic membrane protein targets to enable structure determination and drug discovery efforts.

The role will include the following responsibilities:

Screening phage display libraries against membrane protein targets

Protein engineering of VHH frameworks

Subcloning of plasmid constructs for expression

Biophysical evaluation of VHH hits

Your Background:

PhD (or MSc with equivalent lab experience) in a relevant area of biology

Theoretical and practical expertise in phage display technologies and selection techniques

Experience working with phage antibody libraries and preferably VHH display

Strong and evidenced molecular biology proficiency

Experience of screening techniques (eg ELISA, cell binding assays ...

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